A composite product containing adipose-derived stem cells for treatment of ischemic diseases of the lower extremities by cell therapy

This patent pertains to human adipose-derived adult stem cells, which are multi-potent stem cells. To be more specific, it concerns human adipose-derived multi-potent adult stem cells, which can be maintained in its undifferentiated state through the formation of spheres and have an excellent proliferation rate, as well as the method of extracting and maintaining the said adult stem cells, the method of differentiation of the said multi-potent adult stem cells into neurocytes, adipocytes, chondrocytes, osteoblasts and insulin-secreting pancreatic beta cells, and the cellular treatment agents, containing the said adult stem cells or differentiated cells, for breast tissue formation and treatment of osteoarthritis, osteoporosis and diabetes.

The multi-potent stem cells concerned have the ability to differentiate into osteoblasts, neurocytes, astrocytes, adipocytes, chondroblasts or insulin-secreting pancreatic beta cells, despite being adult stem cells, and thus can be used to effectively treat osteoporosis, osteoarthritis, neural diseases and diabetes and to form breast tissue. Also, spheres are formed in a culture medium containing CORM-2 culture so that they can be kept in their undifferentiated state for a long time, and they also have an outstanding proliferation rate, which makes them useful as a cellular therapeutic agent.

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