The Effects of Mesenchymal Stem Cells Extracted from the Human Adipocytes on Differentiation, Scaffolding and Bone Morphogenetic Proteins (BMPs) in Athymic Rats with Skull Ossification Defects

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects motor neurons in the cortex, brain stem, and spinal cord. The precise pathogenic mechanism remains unknown, and there is currently no effective therapy. We evaluated the therapeutic effects of human adipose tissue-derived stem cells (ASCs) in an animal model of ALS. Human abdominal subcutaneous fat tissues were obtained by simple liposuction from donors, and ASCs were isolated from the fat stromal vascular fraction.

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